The Chase Studio campus is located on over 1500 acres of oak-hickory woodland bordering Mark Twain National Forest and Bull Shoals Lake in southern Missouri.
The property is a microcosm of characteristic Ozark habitats, including rich bottomland forests, upland forests with glades and prairie savannas, moist bluffs, spring-fed streams, and a large cave.
The studio houses one of the largest private natural history collections with over a million specimens, extensive photo and illustration archives, and a natural history library with over 1,500 volumes.
The various exhibit departments are set up to accommodate specific tasks in the nine major buildings on campus with over 30,000 ft² of work space. In addition, the studio has two large warehouses full of exhibit components and thousands of molds.